Inflammatory Mediators (CA125, CRP) and Uric Acid in Association with Severity of Preeclampsia in North Kordofan State, Western Sudan

Introduction: Inflammatory mediators could be laboratory markers of preeclampsia, as the induction an inflammatory process within placenta may trigger expression cancer antigen 125(CA125), C-reactive protein (CRP) and uric acid (UA). Regarding pathophysiology pre-eclampsia, there is defective trophoblastic invasion uteroplacental blood vessels that leads to placental ischemia, placenta.
 Objective: To evaluate association serum levels (CA125), with Severity Preeclampsia.
 Materials Methods: The study recruited 200 singleton Sudanese pregnant women. These participants were divided into two groups: control (n = 100) cases 100). further subdivided into; mild preeclampsia =46), severe 54). groups well-matched in maternal age, gestational age body mass index. Blood samples taken for measurement antigen-CA125, C - reactive using immune- assay enzymatic automated chemical analysis.
 Results: mean antigen-CA125 were; 21.94±5.08 (IU/ml) 40.77±9.82 respectively, which significantly higher, (P<0.001) comparison group (16.88±7.36 (IU/ml). 15.17±5.35 (mg/L), 31.49±12.56 (mg/L) respectively. There was significant difference their levels, compared (4.79±1.78 (P<0.01). Also, 6.44±1.98 7.37±2.00 (4.00±0.61); (P<0.001). level also, showed case (severe mild) (P<0.05). CA125, CRP UA level‎s correlated positively Mean Arterial pressure (MAP), (r>0.7; P < 0.001). ROC curve validate utility these biomarker detection severity (AUC>0. 8; 0.001).
 Conclusion: Serum C- studied found higher group, rises directly associated preeclampsia.